Product Information
Sulphadoxine and pyrimethamine combination is an antimalarial agent, which acts by reciprocal potentiation of its two components, achieved by a sequential blockade of two enzymes involved in the biosynthesis of folinic acid within the parasites. They are blood schizonticidal agents and are active against the asexual erythrocytic forms of susceptible plasmodia. Trophozoites and schizonts are rapidly eliminated from the blood. The pre-erythrocytic stages are also affected, and the gametocytes are rendered non-infective in the mosquito.
Pyrimethamine is a folic acid antagonist and has a mechanism of action similar to that of trimethoprim. By binding to and reversibly inhibiting dihydrofolate reductase, pyrimethamine inhibits the reduction of dihydrofolic acid to tetrahydrofolic acid (folinic acid). Pyrimethamine interferes with the synthesis of tetrahydrofolic acid in malarial parasites at a point immediately succeeding that where sulphonamides act.
Sulphadoxine, like other sulphonamides, is a structural analog of p-aminobenzoic acid (PABA) and competitively inhibits dihydrofolic acid synthesis by inhibiting dihydropteroate synthetase, which is necessary for the conversion of PABA to folic acid.
The combination of sulphadoxine and pyrimethamine results in a synergistic action against susceptible plasmodia. The risk of resistance development is reduced by this means. This attacks the different development stages of the parasite.
Product Packaging
The dosages available for this product are:
- Sulfadoxine + Pyramethamine Tablets 500mg + 25mg
Sulfadoxine Pyramethamine tablets can be packaged as 3 tabs / blister / box, 1,000 boxes / carton, or according to the customer's requirements.
